Clinical role of F-18 fluorodeoxyglucose positron emission tomography imaging in patients with lung cancer and suspected malignant pleural effusion.
نویسندگان
چکیده
STUDY OBJECTIVES The goals of this study were to determine the sensitivity, specificity, and predictive accuracy of F-18 fluorodeoxyglucose positron emission tomography (PET-FDG) imaging in detecting metastatic disease involvement of pleura and/or presence of malignant pleural effusion in patients with proven lung cancer. We wanted to compare efficacy of PET-FDG imaging to CT scanning in differentiating benign pleural effusion from malignant effusion and/or pleural involvement in patients with lung cancer. METHODS We studied 35 patients with biopsy-proven lung cancer and abnormal findings on CT scanning for presence of pleural effusion (n = 34) and/or pleural thickening or nodular involvement (n = 4). The results of positron emission tomography and CT scanning were compared to pleural cytology (n = 31), histologic findings of pleural biopsy (n = 3), and/or clinical follow-up (n = 3) for at least 1 year for presence or absence of malignant pleural effusion. RESULTS PET-FDG imaging correctly detected the presence of malignant pleural effusion and malignant pleural involvement in 16 of 18 patients and excluded malignant effusion or pleural metastatic involvement in 16 of 17 patients (sensitivity, specificity, and accuracy of 88.8%, 94.1%, and 91.4% respectively). CONCLUSION PET-FDG imaging is a highly accurate and reliable noninvasive test to differentiate malignant from benign pleural effusion and/or pleural involvement in patients with lung cancer and findings of suspected malignant pleural effusion on CT scanning.
منابع مشابه
Fluorine-18-FDG-PET Demonstrating Malignant Pleural Effusion from Esophageal Carcinoma
Received 10/13/2006; revised 11/22/2006; accepted 11/29/2006. For correspondence or reprints contact: Shiou-Chi Cherng, M.D., Department of Nuclear Medicine, Tri-Service General Hospital. 325 Section 2, Cheng-Kung Road, Nei-Hu Distinct, Taipei 114, Taiwan, ROC. Tel: (886)2-87927374, Fax: (886)2-87927217, E-mail: [email protected] Malignant pleural effusion is the most common complicated by p...
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ورودعنوان ژورنال:
- Chest
دوره 122 6 شماره
صفحات -
تاریخ انتشار 2002